Cell-Specific Transcriptomic and Mito-Nuclear Imbalance in Lungs Under Intermittent Hypoxia in Adult Male Mice

Abstract excerpt

Obstructive sleep apnea and its characteristic intermittent hypoxia (IH) are widely recognized as significant contributors to various pulmonary diseases, including asthma, pulmonary arterial hypertension, fibrosis, and chronic obstructive pulmonary disease. While single-cell RNA sequencing (scRNA-seq) has provided valuable insights into cell-type-specific responses to IH, previous studies have primarily focused on...

Topics

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• Congenital Diaphragmatic Hernia Studies
• Extracellular vesicles in disease
• Fibroblast Growth Factor Research
• Neonatal Respiratory Health Research
• Neuroscience of respiration and sleep
• Obstructive Sleep Apnea Research
• Pulmonary Hypertension Research and Treatments
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

c3891c74-f4e8-58a5-a3fd-8ae121bf5203

DOI

10.1101/2025.08.05.668735