Article

Cell-Specific Transcriptome of the COPD Alveolar Niche

2021-03-11

Abstract excerpt

<title>Abstract</title> <p>Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of death worldwide. To identify cell-specific mechanisms underlying COPD pathobiology, we analysed single-cell RNA sequencing (scRNAseq) profiles of explanted lung tissue from subjects with advanced COPD or control lungs. Findings were validated with scRNAseq of lungs from mice exposed to 10 months of cigarette smoke (CS),...

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Literature Corpus work: 6b9622af-f07e-58b4-af10-564dddcbb9e2
DOI: 10.21203/rs.3.rs-276195/v1

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