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Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis

27 Jun 2024

Abstract excerpt

Progressive lung fibrosis is associated with poorly understood aging-related endothelial cell dysfunction. To gain insight into endothelial cell alterations in lung fibrosis we performed single cell RNA-sequencing of bleomycin-injured lungs from young and aged mice. Analysis reveals activated cell states enriched for hypoxia, glycolysis and YAP/TAZ activity in ACKR1+ venous and TrkB+ capillary endothelial cells....

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PMID: 38937456
DOI: 10.1038/s41467-024-49545-x

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