Article

Nicotinamide opposes ET-1’s adverse effect on uterine decidualization via EDNRB

2025-09-19

Abstract excerpt

Endothelin-1 is involved in pathogenesis of preeclampsia. Mice ( Edn1 H/+ ) having excess endothelin-1 developed preeclampsia-like phenotypes during pregnancy in a maternal genotype-dependent manner. Here, we investigate whether decidualization is impaired in Edn1 H/+ dams, and whether nicotinamide (a potent inhibitor of endothelin-1) exerts beneficial effect. We compared implantation sites between wild type (WT...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c388ce11-97c2-5f67-b24e-b351d8320e21
DOI: 10.1101/2025.09.18.677237

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nicotinamide opposes ET-1’s adverse effect on uterine decidualization via EDNRBDOI 10.1101/2025.09.18.677237Read

Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsiaSemantic proximity Read

A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsiaSemantic proximity Read

High-salt diet disturbs the physiological uterine endothelial junction remodeling during pregnancySemantic proximity Read

Runx1 regulates critical factors that control uterine angiogenesis and trophoblast differentiation during placental developmentSemantic proximity Read

Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological PlacentationSemantic proximity Read

Aspirin alleviates fibronectin-induced preeclampsia phenotypes in a mouse model and reverses fibronectin-mediated trophoblast invasiveness under hypoxia by regulating ciliogenesis and Akt and MAPK signaling.Semantic proximity Read

Estrogen induces EGR1 to fine‐tune its actions on uterine epithelium by controlling PR signaling for successful embryo implantationSemantic proximity Read

Runx1 regulates critical factors that control uterine angiogenesis and trophoblast differentiation during placental developmentSemantic proximity Read

Expression of the vascular endothelial growth factor receptor neuropilin-1 at the human embryo–maternal interfaceSemantic proximity Read

ELABELA deficiency promotes preeclampsia and cardiovascular malformations in miceSemantic proximity Read

Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice.Semantic proximity Read

IGF2BP2 Mediated the Positive Effects of the NAD + in the Decidualization of the Human Endometrial Stromal CellsSemantic proximity Read