Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia

21 Jun 2011

Abstract excerpt

Placental trophoblasts (TBs) invade and remodel uterine vessels with an arterial bias. This process, which involves vascular mimicry, re-routes maternal blood to the placenta, but fails in pre-eclampsia. We investigated Notch family members in both contexts, as they play important roles in arterial differentiation/function. Immunoanalyses of tissue sections showed step-wise modulation of Notch receptors/ligands...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Syndromes and Imprinting
Share to MicroRNA in disease regulation
Share to Pregnancy and preeclampsia studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21693515
DOI: 10.1242/dev.066589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsiaPMID 21693515Read ↗

NOTCH, WNT, and TGFβ: Key pathways in extravillous trophoblast formation and differentiationSemantic proximity Read ↗

Human placenta and trophoblast development: key molecular mechanisms and model systemsSemantic proximity Read ↗

The Interplay of Molecular Factors and Morphology in Human Placental Development and ImplantationSemantic proximity Read ↗

Human placental trophoblast invasion and differentiation: a particular focus on Wnt signalingSemantic proximity Read ↗

Spatially resolved single-cell multiomics map of human trophoblast differentiation in early pregnancySemantic proximity Read ↗

Development and function of trophoblast giant cells in the rodent placentaSemantic proximity Read ↗

Function and control of human invasive trophoblast subtypes: Intrinsic vs. maternal controlSemantic proximity Read ↗

WNT and NOTCH signaling in human trophoblast development and differentiationSemantic proximity Read ↗

Feto-placental blood vessel developmentSemantic proximity Read ↗

Spatial multiomics map of trophoblast development in early pregnancySemantic proximity Read ↗

3D imaging of the pregnant uterus reveals an extensively invasive mouse placenta and early CXCL12-CXCR4 requirementSemantic proximity Read ↗

Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodelingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.