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Article

Transfer learning with false negative control improves polygenic risk prediction.

PLoS genetics - 1 Nov 2023

Jeng Xinge Jessie, Hu Yifei, Venkat Vaishnavi, Lu Tzu-Pin, Tzeng Jung-Ying

Abstract excerpt

Polygenic risk score (PRS) is a quantity that aggregates the effects of variants across the genome and estimates an individual's genetic predisposition for a given trait. PRS analysis typically contains two input data sets: base data for effect size estimation and target data for individual-level prediction. Given the availability of large-scale base data, it becomes more common that the ancestral background of...

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PMID: 38011285
DOI: 10.1371/journal.pgen.1010597
PMCID: PMC10723713

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