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Article

Defective glycosylation and ELFN1 binding of mGluR6 congenital stationary night blindness mutants.

Life science alliance - 1 Mar 2025

Pindwarawala Mustansir, Abid Faiyaz Ak, Lee Jaeeun, Miller Michael L, Noppers Juliet S, Rideout Andrew P, Agosto Melina A

Abstract excerpt

Synaptic transmission from photoreceptors to ON-bipolar cells (BCs) requires the postsynaptic metabotropic glutamate receptor mGluR6, located at BC dendritic tips. Binding of the neurotransmitter glutamate initiates G protein signaling that regulates the TRPM1 transduction channel. mGluR6 also interacts with presynaptic ELFN adhesion proteins, and these interactions are important for mGluR6 synaptic localization....

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Share to Congenital Disorders of Glycosylation
Share to Eye Diseases, Hereditary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Glutamate

Share to Receptors, Metabotropic Glutamate

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Source

Open in PubMed Open full text

Identifiers

PMID: 39681475
DOI: 10.26508/lsa.202403118
PMCID: PMC11649943

Genes

TRPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Defective glycosylation and ELFN1 binding of mGluR6 congenital stationary night blindness mutants.PMID 39681475Read ↗

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