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Article

Involvement of the C-terminal domain in cell surface localization and G-protein coupling of mGluR6.

Journal of neurochemistry - 1 Aug 2021

Rai Dilip, Akagi Takumi, Shimohata Atsushi, Ishii Toshiyuki, Gangi Mie, Maruyama Takuma, Wada-Kiyama Yuko, Ogiwara Ikuo, Kaneda Makoto

Abstract excerpt

Metabotropic glutamate receptor 6, mGluR6, interacts with scaffold proteins and Gβγ subunits via its intracellular C-terminal domain (CTD). The mGluR6 pathway is critically involved in the retinal processing of visual signals. We herein investigated whether the CTD (residues 840-871) was necessary for mGluR6 cell surface localization and G-protein coupling using mGluR6-CTD mutants with immunocytochemistry,...

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PMID: 33067823
DOI: 10.1111/jnc.15217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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