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Article

Altered G-protein coupling in an mGluR6 point mutant associated with congenital stationary night blindness.

Molecular pharmacology - 1 Nov 2009

Beqollari Donald, Betzenhauser Matthew J, Kammermeier Paul J

Abstract excerpt

The highly specialized metabotropic glutamate receptor type 6 (mGluR6) is postsynaptically localized and expressed only in the dendrites of ON bipolar cells. Upon activation of mGluR6 by glutamate released from photoreceptors, a nonselective cation channel is inhibited, causing these cells to hyperpolarize. Mutations in this gene have been implicated in the development of congenital stationary night blindness...

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Source

Identifiers

PMID: 19666700
DOI: 10.1124/mol.109.058628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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