Article

Saturated mutagenesis screen of M-MLV reverse transcriptase identifies variants enhancing prime editing efficiency

2026-07-07

Abstract excerpt

Prime editing enables the precise modification of genomes, thereby holding great potential for the treatment of genetic diseases. Despite substantial advancements in prime editing technology and the initiation of the first clinical trial for treating chronic granulomatous disease, further enhancement of editing efficiency across edit types is still urgently needed. Here, we developed a compact prime editor, PE2ΔR,...

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Literature Corpus work: c328865c-e5cc-527e-8e12-308a3cdb058b
DOI: 10.64898/2026.07.06.736660

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