Article

Identifying <i>in vivo</i> genetic dependencies of melanocyte and melanoma development

2024-03-23

Abstract excerpt

The advent of large-scale sequencing in both development and disease has identified large numbers of candidate genes that may be linked to important phenotypes. We have developed a rapid, scalable system for assessing the role of candidate genes using zebrafish. We generated transgenic zebrafish in which Cas9 was knocked-in to the endogenous mitfa locus, a master transcription factor of the melanocyte lineage. Th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c32652c6-625d-5b18-a01b-2ed202aefb3e
DOI: 10.1101/2024.03.22.586101

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identifying <i>in vivo</i> genetic dependencies of melanocyte and melanoma developmentDOI 10.1101/2024.03.22.586101Read

Developmental pathways activated in melanocytes and melanoma.Semantic proximity Read

Dissecting Oncogenic RAS Signaling in Melanoma Development in Genetically Engineered Zebrafish Models.Semantic proximity Read

GNAQ Induces Melanomagenesis in Mitfa-Independent Melanocyte Progenitors in a Zebrafish Model of Uveal MelanomaSemantic proximity Read

Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual DiseaseSemantic proximity Read

Specific <i>SOX10</i> enhancer elements modulate phenotype plasticity and drug resistance in melanomaSemantic proximity Read

Loss of <i>prdm1a</i> accelerates melanoma onset and progressionSemantic proximity Read

Loss of MITF activity leads to emergent cell states from the melanocyte stem cell lineageSemantic proximity Read

A conditional zebrafish MITF mutation reveals MITF levels are critical for melanoma promotion vs. regression in vivo.Semantic proximity Read

Proof of concept study deploying CRISPR inhibition and activation opens new avenues for systematic biological exploration in zebrafishSemantic proximity Read

Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish.Semantic proximity Read

Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)Semantic proximity Read

Deciphering Melanoma Cell States and Plasticity with Zebrafish Models.Semantic proximity Read