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Article

Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish.

Zebrafish - 1 Dec 2009

Dovey Michael, White Richard Mark, Zon Leonard I

Abstract excerpt

NRAS mutations are a common oncogenic event in skin cancer, occurring frequently in congenital nevi and malignant melanoma. To study the role of NRAS in zebrafish, a transgenic approach was applied to generate fish that express human oncogenic NRAS(Q61K) under the control of the melanocyte-restricted mitfa promoter. By screening the progeny of the injected animals, two strains stably expressing the NRAS transgene...

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Identifiers

PMID: 19954345
DOI: 10.1089/zeb.2009.0606
PMCID: PMC2943216

Genes

NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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