Article

Making of fusion genes in cancer: An in-silico study of mechanism of chromosomal translocations

2018-02-24

Abstract excerpt

Chromosomal translocations involve exchange of genetic material between non- homologous chromosomes leading to the formation of a fusion gene with altered function. The clinical consequences of non-random and recurrent chromosomal translocations have been so well understood in carcinogenesis that they serve as diagnostic and prognostic markers and also help in therapy decisions, mainly in leukemia and lymphoma. Ho...

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Literature Corpus work: c31b2693-f0b8-5038-9ea7-1adf82507e53
DOI: 10.7287/peerj.preprints.26571v1

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