Article

CFIm25 regulates human stem cell function independently of its role in mRNA alternative polyadenylation

2021-12-08

Abstract excerpt

It has recently been shown that CFIm25, a canonical mRNA 3’ processing factor, could play a variety of physiological roles through its molecular function in the regulation of mRNA alternative polyadenylation (APA). Here, we used CRISPR/Cas9-mediated gene editing approach in human embryonic stem cells (hESCs) for CFIm25, and obtained three gene knockdown/mutant cell lines. CFIm25 gene editing resulted in higher pro...

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Literature Corpus work: c312ab2b-d98a-59e7-9d1e-445c8b730533
DOI: 10.1101/2021.12.08.471721

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