Article

Gene inactivation in the citrus pathogenic fungus Alternaria alternata defect at the Ku70 locus associated with non-homologous end joining

2011-08-01

Abstract excerpt

Low frequency of targeted gene disruption in filamentous fungi has been attributed to the predominance of ectopic integration that is controlled by a non-homologous end-joining (NHEJ) DNA repair mechanism. It has been shown in a number of fungi that suppression of NHEJ by inactivating the yeast Ku70 or Ku80 homolog facilitates homologous recombination, thereby enhancing the frequency of gene targeting. A Ku70 gene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c30dc563-d46a-54f7-9950-f3a390155387
DOI: 10.1007/s11274-010-0640-z

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene inactivation in the citrus pathogenic fungus Alternaria alternata defect at the Ku70 locus associated with non-homologous end joiningDOI 10.1007/s11274-010-0640-zRead

Highly efficient gene targeting in the Aspergillus niger kusA mutant.Semantic proximity Read

The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus.Semantic proximity Read

Highly efficient generation of signal transduction knockout mutants using a fungal strain deficient in the mammalian ku70 ortholog.Semantic proximity Read

Ku70 or Ku80 deficiencies in the fungus Botrytis cinerea facilitate targeting of genes that are hard to knock out in a wild-type context.Semantic proximity Read

A versatile and efficient gene-targeting system for Aspergillus nidulans.Semantic proximity Read

A ku70 null mutant improves gene targeting frequency in the fungal pathogen Verticillium dahliae.Semantic proximity Read

Highly efficient gene replacements in Neurospora strains deficient for nonhomologous end-joining.Semantic proximity Read

Gene targeting in a nonhomologous end joining deficient Hypocrea jecorina.Semantic proximity Read

Transient disruption of non-homologous end-joining facilitates targeted genome manipulations in the filamentous fungus Aspergillus nidulans.Semantic proximity Read

Disruption of the Arabidopsis AtKu80 gene demonstrates an essential role for AtKu80 protein in efficient repair of DNA double-strand breaks in vivo.Semantic proximity Read

How the Pathogenic Fungus Alternaria alternata Copes with Stress via the Response Regulators SSK1 and SHO1.Semantic proximity Read

A high throughput targeted gene disruption method for Alternaria brassicicola functional genomics using linear minimal element (LME) constructs.Semantic proximity Read