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Article

The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus.

Eukaryotic cell - 1 Jan 2006

da Silva Ferreira Márcia Eliana, Kress Marcia R V Z, Savoldi Marcela, Goldman Maria Helena S, Härtl Albert, Heinekamp Thorsten, Brakhage Axel A, Goldman Gustavo H

Abstract excerpt

To increase the frequency of homologous recombination, we inactivated the KU80 homologue in Aspergillus fumigatus (named akuB(KU80)). Homologous integration reached about 80% for both calcineurin A (calA) and polyketide synthase pksP (alb1) genes in the akuB(KU80) mutant to 3 and 5%, respectively, when using a wild-type A. fumigatus strain. Deletion of akuB(KU80) had no influence on pathogenicity in a low-dose...

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Identifiers

PMID: 16400184
DOI: 10.1128/EC.5.1.207-211.2006
PMCID: PMC1360264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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