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Article

VAPB interacts with and modulates the activity of ATF6

7 Feb 2008

Abstract excerpt

A mis-sense point mutation in the human VAPB gene is associated with a familial form of motor neuron disease that has been classified as Amyotrophic Lateral Sclerosis type VIII. Affected individuals suffer from a spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS) or an atypical slowly progressing form of ALS. Mammals have two homologous VAP genes, vapA and vapB. VAPA and VAPB share 76% similar or...

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PMID: 18263603
DOI: 10.1093/hmg/ddn040

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