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Article

A mutation in human VAP-B--MSP domain, present in ALS patients, affects the interaction with other cellular proteins.

Protein expression and purification - 1 Sept 2007

Mitne-Neto M, Ramos C R R, Pimenta D C, Luz J S, Nishimura A L, Gonzales F A, Oliveira C C, Zatz M

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is the most common adult-onset Motor Neuron Disease (MND), characterized by motor neurons death in the cortex, brainstem and spinal cord. Ten loci linked to Familial ALS have been mapped. ALS8 is caused by a substitution of a proline by a serine in the Vesicle-Associated Membrane Protein-Associated protein-B/C (VAP-B/C). VAP-B belongs to a highly conserved family of proteins...

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Source

Identifiers

PMID: 17540579
DOI: 10.1016/j.pep.2007.04.007

Genes

GAPDH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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A mutation in human VAP-B--MSP domain, present in ALS patients, affects the interaction with other cellular proteins.PMID 17540579Read ↗

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