Polygenic architecture of rare coding variation across 394,783 exomes.

Abstract excerpt

Both common and rare genetic variants influence complex traits and common diseases. Genome-wide association studies have identified thousands of common-variant associations, and more recently, large-scale exome sequencing studies have identified rare-variant associations in hundreds of genes1-3. However, rare-variant genetic architecture is not well characterized, and the relationship between common-variant and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bipolar Disorder
• Share to Exome
• Share to Gene Frequency