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Article

Conserved metabolic vulnerabilities across pathogenic coronaviruses nominate host-directed therapeutic targets

2026-04-20

Abstract excerpt

<h4>SUMMARY</h4> Pathogenic coronaviruses profoundly rewire host cell metabolism to support viral replication, yet whether these metabolic alterations expose shared and actionable vulnerabilities remains unclear. By integrating transcriptomic profiles from cells infected with SARS-CoV, SARS-CoV-2, and MERS-CoV with genome-scale metabolic models, we identify conserved and virus-specific metabolic perturbations aff...

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Literature Corpus work
c2cf9e4e-bb4d-56f9-9ebc-69417160e31d
DOI
10.64898/2026.04.17.716662
Open publication

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Conserved metabolic vulnerabilities across pathogenic coronaviruses nominate host-directed therapeutic targetsDOI 10.64898/2026.04.17.716662
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