Rapid discovery of antiviral targets through dimensionality reduction of genome-scale metabolic models

Abstract excerpt

The COVID-19 pandemic underscored the urgent need for rapid and broadly applicable strategies to identify antiviral targets against emerging pathogens. Conventional approaches, which rely on detailed viral characterization and large-scale drug screening, are too slow to address this challenge. Here, we introduce a transcriptome-based computational framework that integrates genome-scale metabolic models with dimens...

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• Bioinformatics and Genomic Networks
• Diet and metabolism studies
• Liver Disease Diagnosis and Treatment
• Metabolomics and Mass Spectrometry Studies

Identifiers and source

Literature Corpus work

f1edbdb9-67df-52e5-8a45-51059008f168

DOI

10.1101/2025.10.02.679942