Article

Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10

2023-09-26

Abstract excerpt

<h4>ABSTRACT</h4> Antiviral signaling, immune response and cell metabolism in human body are dysregulated by SARS-CoV-2, the causative agent of the COVID-19. Here, we show that SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 induce a significant mitochondrial and metabolic reprogramming in A549 lung epithelial cells. While all four ORFs caused mitochondrial fragmentation and altered mitochondrial func...

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Literature Corpus work: f3e1cf84-7c13-5652-b637-c8b908f40c6f
DOI: 10.1101/2023.09.26.559506

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