Predictive Systems Biology Modeling: Unraveling Host Metabolic Disruptions and Potential Drug Targets in Acute Viral Infections

Abstract excerpt

<h4>Background</h4> Host response is critical to the onset, progression, and outcome of viral infections. Since viruses hijack the host cellular metabolism for their replications, we hypothesized that restoring host cell metabolism can efficiently reduce viral production. <h4>Results</h4> Here, we present a viral-host Metabolic Modeling (vhMM) method to systematically evaluate the disturbances in host metabolism...

Topics

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• COVID-19 Clinical Research Studies
• Diet and metabolism studies
• Liver Disease Diagnosis and Treatment
• Long-Term Effects of COVID-19
• Metabolomics and Mass Spectrometry Studies
• Microbial Metabolic Engineering and Bioproduction
• Mosquito-borne diseases and control
• Tryptophan and brain disorders

Identifiers and source

Literature Corpus work

9a5d0e3b-4148-5f8d-9c9a-bf1beaaa1ecf

DOI

10.1101/2023.07.24.550423