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Supramolecular Biomimetic Topology: Macrophage-Engaged Neoadjuvant Platform for Preoperative Immunotherapy

2025-03-13

Abstract excerpt

The persistent immunosuppression and spatial heterogeneity of advanced solid tumors necessitate next-generation neoadjuvant platforms capable of reprogramming tumor microenvironments while overcoming resistance to immune checkpoint blockade. Addressing this unmet clinical challenge, we report a β-glucan-empowered nano-neoadjuvant agents (NNAs) engineered through topology-guided supramolecular assembly of pathogen-...

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Literature Corpus work
c28d5b6f-9972-515d-8340-7ce0da79eaba
DOI
10.1101/2025.03.11.639123
Open publication

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Supramolecular Biomimetic Topology: Macrophage-Engaged Neoadjuvant Platform for Preoperative ImmunotherapyDOI 10.1101/2025.03.11.639123
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