Back to search

Article

Supramolecular Biomimetic Topology: Macrophage-Engaged Neoadjuvant Platform for Preoperative Immunotherapy

2025-03-10

Abstract excerpt

The persistent immunosuppression and spatial heterogeneity of advanced solid tumors necessitate next-generation neoadjuvant platforms capable of reprogramming tumor microenvironments while overcoming resistance to immune checkpoint blockade. Addressing this unmet clinical challenge, we report a β-glucan-empowered nano-neoadjuvant agents (NNAs) engineered through topology-guided supramolecular assembly of pathogen-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7f00bab3-4320-52fe-9536-e6b792f36b9d
DOI
10.1101/2025.03.02.641066
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Supramolecular Biomimetic Topology: Macrophage-Engaged Neoadjuvant Platform for Preoperative ImmunotherapyDOI 10.1101/2025.03.02.641066
Supramolecular Biomimetic Topology: Macrophage-Engaged Neoadjuvant Platform for Preoperative ImmunotherapySemantic proximity
Neoantigen enriched biomimetic nanovaccine for personalized cancer immunotherapySemantic proximity
Exploring the theranostic potential of carbon dots/Fe3 O4 superparticles for tumor-associated macrophage targeting and repolarization in colorectal cancer therapy via JAK/STAT and ERK/MAPK pathwaysSemantic proximity
CNTs as Excellent Adjuvants for Anticancer Therapeutic Strategies and Cancer Diagnosis: A Plethora of Laboratory Studies versus Few Clinical Trials and Still No Clinical ApplicationSemantic proximity
CarboCell combinatorial immunotherapy orchestrates curative anticancer immune activation of the tumor microenvironmentSemantic proximity
Ultrasound-Activated Nanobubbles Induce Durable Systemic Antitumor ImmunitySemantic proximity
Programable Albumin-Hitchhiking Nanobodies Enhance the Delivery of STING Agonists to Potentiate Cancer ImmunotherapySemantic proximity
PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer.Semantic proximity
A homologous-targeting "nanoconverter" with variable size for deep tumor penetration and immunotherapy.Semantic proximity
Repolarizing Neutrophils via MnO2 Nanoparticle-Activated STING Pathway Enhances Salmonella-Mediated Tumor ImmunotherapySemantic proximity
Targeted Delivery of STING agonist via Albumin Nanoreactor Boosts Immunotherapeutic Efficacy against Aggressive CancersSemantic proximity
From Phenomenon to Precision: Addressing Key Challenges in Harnessing Nanomaterial-Induced Biological Responses for Cancer TherapySemantic proximity
Select a neighboring publication to make it the new centre.