Article

Repolarizing Neutrophils via MnO2 Nanoparticle-Activated STING Pathway Enhances Salmonella-Mediated Tumor Immunotherapy

2024-03-29

Abstract excerpt

<title>Abstract</title> <p>Engineered <italic>Salmonella</italic> has emerged as a promising microbial immunotherapy against tumors; however, its clinical effectiveness has encountered limitations. In our investigation, we unveil a non-dose-dependent type of behavior regarding <italic>Salmonella</italic>’s therapeutic impact and reveal the regulatory role of neutrophils in diminishing the efficacy of this. While...

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Literature Corpus work: f79c0be0-ff90-5612-98b3-16bb7f503f0a
DOI: 10.21203/rs.3.rs-4147985/v1

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