Article

The Goldilocks Principle of JAKs and STATs: Gain-of function mutations, loss-of-function mutations, and their clinical consequences

2022-08-19

Abstract excerpt

<title>Abstract</title> <p>The JAK-STAT signalling pathway plays a key role in cytokine signalling and is involved in development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK-STAT signalling pathway appears to be straight forward. However, on closer examination, there are many different factors influencing the JAK and the STAT proteins, which even so cannot sufficiently explain the w...

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Literature Corpus work: c273b2a4-ac57-54fa-9ae3-4743944ab4fa
DOI: 10.21203/rs.3.rs-1948968/v1

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