Human diseases caused by impaired signal transducer and activator of transcription and Janus kinase signaling.

Abstract excerpt

PURPOSE OF REVIEW: The Janus kinase (JAK) and signal transducer of activation (STAT) pathway plays a key role in the immune system. It is employed by diverse cytokines, interferons, growth factors and related molecules. Mutations in JAK/STAT pathway have been implicated in human disease. Here we review JAK/STAT biology and diseases associated with mutations in this pathway. RECENT FINDINGS: Over the past 10...

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