Article

SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients

2020-08-25

Abstract excerpt

<h4>ABSTRACT</h4> Although COVID-19 causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. Exposure of human iPSC-derived heart cells to SARS-CoV-2 revealed productive infection and robust transcriptomic and morphological signatures of damage, particularly in cardiomyocytes. Transcriptomic disruption of structural proteins corroborated adverse morphologic features, which included a...

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Literature Corpus work: fd2f525b-2e4c-5e41-81df-0c3b25de42d6
DOI: 10.1101/2020.08.25.265561

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