Article

Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injuries

2022-02-01

Abstract excerpt

Acute cardiac injuries occur in 20-25% of hospitalized COVID-19 patients. Despite urgent needs, there is a lack of 3D organotypic models of COVID-19 hearts for mechanistic studies and drug testing. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1βis an upstream cytokine and a core COVID-19 signature cytokine...

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Literature Corpus work: 238ea1b9-79de-50f3-9772-17cd14c5c4cc
DOI: 10.1101/2022.01.31.478497

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