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The memory of pathogenic IgE is contained within CD23 + IgG1 + memory B cells poised to switch to IgE in food allergy

2023-01-25

Abstract excerpt

Food allergy is caused by allergen-specific IgE antibodies but little is known about the B cell memory of persistent IgE responses. Here we describe in human pediatric peanut allergy CD23 + IgG1 + memory B cells arising in type 2 responses that contain peanut specific clones and generate IgE cells on activation. These ‘type2-marked’ IgG1 + memory B cells differentially express IL-4/IL-13 regulated genes FCER2...

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Literature Corpus work: 41890ede-9d81-56c2-b88d-f411cb43d561
DOI: 10.1101/2023.01.25.525506

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The memory of pathogenic IgE is contained within CD23 <sup>+</sup> IgG1 <sup>+</sup> memory B cells poised to switch to IgE in food allergy

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