Article
Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice.
Science translational medicine - 1 May 2013
Huang Jianbin, Yamashiro Yoshito, Papke Christina L, Ikeda Yuichi, Lin Yanling, Patel Miteshkumar, Inagami Tadashi, Le Victoria P, Wagenseil Jessica E, Yanagisawa Hiromi
Abstract excerpt
Aortic aneurysms are life-threatening and often associated with defects in connective tissues and mutations in smooth muscle cell (SMC) contractile proteins. Despite recent advances in understanding altered signaling in aneurysms of Marfan syndrome, the underlying mechanisms and options for pharmacological treatment for other forms of aneurysms are still under investigation. We previously showed in mice that...
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