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Melatonin and sirtuins: A “not‐so unexpected” relationship

21 Jan 2017

Abstract excerpt

Epigenetic modifications, including methylation or acetylation as well as post-transcriptional modifications, are mechanisms used by eukaryotic cells to increase the genome diversity in terms of differential gene expression and protein diversity. Among these modifying enzymes, sirtuins, a class III histone deacetylase (HDAC) enzymes, are of particular importance. Sirtuins regulate the cell cycle, DNA repair, cell...

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PMID: 28109165
DOI: 10.1111/jpi.12391

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