Article

Triazolopyrimidines target aerobic respiration in <i>Mycobacterium tuberculosis</i>

2021-10-20

Abstract excerpt

We previously identified a series of triazolopyrimidines with anti-tubercular activity. We determined that Mycobacterium tuberculosis strains with mutations in a component of the cytochrome bc 1 system (QcrB) were resistant to the series. A cytochrome bd oxidase deletion strain was also more sensitive to this series. We isolated resistant mutants, all of which had mutations in Rv1339. Compounds were active aga...

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Literature Corpus work: c232c3ff-172a-550b-9b67-87a4e2f28766
DOI: 10.1101/2021.10.18.464924

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