Article

Structural and mechanistic study of a novel inhibitor of M. tuberculosis cytochrome bc1:aa3

2025-01-30

Abstract excerpt

<title>Abstract</title> <p>Drug-resistant tuberculosis (TB) continues to challenge treatment options, necessitating the exploration of new compounds of novel targets. The mycobacterial respiratory complex cytochrome bc1:aa3 has emerged as a promising target, exemplified by the success of first-in-class inhibitor Q203 in phase 2 clinical trial. However, to fully exploit the potential of this target and to identify...

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Literature Corpus work: 6a705dfb-1661-566f-8030-841d0b8fdc2c
DOI: 10.21203/rs.3.rs-5630670/v1

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