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Article

New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis.

PLoS pathogens - 1 Jan 2020

Lupien Andréanne, Foo Caroline Shi-Yan, Savina Svetlana, Vocat Anthony, Piton Jérémie, Monakhova Natalia, Benjak Andrej, Lamprecht Dirk A, Steyn Adrie J C, Pethe Kevin, Makarov Vadim A, Cole Stewart T

Abstract excerpt

The emergence of multi-drug (MDR-TB) and extensively-drug resistant tuberculosis (XDR-TB) is a major threat to the global management of tuberculosis (TB) worldwide. New chemical entities are of need to treat drug-resistant TB. In this study, the mode of action of new, potent quinazoline derivatives was investigated against Mycobacterium tuberculosis (M. tb). Four derivatives 11626141, 11626142, 11626252 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31971990
DOI: 10.1371/journal.ppat.1008270
PMCID: PMC6999911

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