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Article

Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis

2 Nov 2011

Abstract excerpt

OBJECTIVES: New classes of drugs are needed to treat tuberculosis (TB) in order to combat the emergence of resistance to existing agents and shorten the duration of therapy. Targeting DNA gyrase is a clinically validated therapeutic approach using fluoroquinolone antibiotics to target the gyrase subunit A (GyrA) of the heterotetramer. Increasing resistance to fluoroquinolones has driven interest in targeting the...

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PMID: 22052686
DOI: 10.1093/jac/dkr449

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