Article
The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress.
Scientific reports - 27 May 2015
Lu Ping, Heineke Marieke H, Koul Anil, Andries Koen, Cook Gregory M, Lill Holger, van Spanning Rob, Bald Dirk
Abstract excerpt
Targeting respiration and ATP synthesis has received strong interest as a new strategy for combatting drug-resistant Mycobacterium tuberculosis. Mycobacteria employ a respiratory chain terminating with two branches. One of the branches includes a cytochrome bc1 complex and an aa3-type cytochrome c oxidase while the other branch terminates with a cytochrome bd-type quinol oxidase. In this communication we show...
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