Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels.

Antimicrobial agents and chemotherapy - 1 Jun 2018

O'Malley Theresa, Alling Torey, Early Julie V, Wescott Heather A, Kumar Anuradha, Moraski Garrett C, Miller Marvin J, Masquelin Thierry, Hipskind Philip A, Parish Tanya

Abstract excerpt

The imidazopyridines are a promising new class of antitubercular agents with potent activity in vitro and in vivo We isolated mutants of Mycobacterium tuberculosis resistant to a representative imidazopyridine; the mutants had large shifts (>20-fold) in MIC. Whole-genome sequencing revealed mutations in Rv1339, a hypothetical protein of unknown function. We isolated mutants resistant to three further compounds...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Antitubercular Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport Complex IV

Share to Imidazoles

Share to Microbial Sensitivity Tests

Share to Mycobacterium tuberculosis

Share to Pyridines

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 29632008
DOI: 10.1128/AAC.02439-17
PMCID: PMC5971599

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels.PMID 29632008Read ↗

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrBSemantic proximity Read ↗

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.Semantic proximity Read ↗

Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.Semantic proximity Read ↗

Hit Compounds and Associated Targets in Intracellular Mycobacterium tuberculosis.Semantic proximity Read ↗

Identification of the anti-mycobacterial functional properties of piperidinol derivatives.Semantic proximity Read ↗

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.Semantic proximity Read ↗

Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human PathogensSemantic proximity Read ↗

A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3Semantic proximity Read ↗

The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bdSemantic proximity Read ↗

Thienopyrimidine amide analogs target MmpL3 in Mycobacterium tuberculosis.Semantic proximity Read ↗

New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis.Semantic proximity Read ↗

Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against Mycobacterium tuberculosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.