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Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas

2026-06-21

Abstract excerpt

Immunotherapy approaches have shown limited efficacy in pediatric sarcomas, partly because these tumors have low mutation burden and few neoantigens. We sought to increase the immunogenicity of low mutation sarcomas by inducing expression of epigenetically silenced genes using the hypomethylating agent decitabine and histone deacetylase inhibitor entinostat. Using a mutated Kras-driven murine sarcoma model KP Sarc...

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Literature Corpus work
c224fb22-0c48-5be5-aa96-eaae683395f5
DOI
10.64898/2026.06.18.733244
Open publication

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Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomasDOI 10.64898/2026.06.18.733244
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