Article
Radiation-induced neoantigens broaden the immunotherapeutic window of cancers with low mutational loads.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 2021
Lussier Danielle M, Alspach Elise, Ward Jeffrey P, Miceli Alexander P, Runci Daniele, White J Michael, Mpoy Cedric, Arthur Cora D, Kohlmiller Heather N, Jacks Tyler, Artyomov Maxim N, Rogers Buck E, Schreiber Robert D
Abstract excerpt
Immunotherapies are a promising advance in cancer treatment. However, because only a subset of cancer patients benefits from these treatments it is important to find mechanisms that will broaden the responding patient population. Generally, tumors with high mutational burdens have the potential to express greater numbers of mutant neoantigens. As neoantigens can be targets of protective adaptive immunity, highly...
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