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Article

Oncogene Mutations: The Shared Antigen Vaccines That Work?

Annual review of medicine - 1 Jan 2026

Paredes Rodrigo, Haldar S Daniel, Pant Shubham, O'Reilly Eileen M

Abstract excerpt

Cancer immunotherapy has advanced through immune checkpoint inhibitors and T cell therapies, yet challenges persist in overcoming immune evasion. Neoantigen-based vaccines have shown promise, particularly in tumors with high tumor mutation burden. However, logistical barriers and tumor heterogeneity limit their scalability. Shared oncogenic driver mutations (e.g., KRAS, EGFR, IDH) offer a stable and broadly...

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Share to Antigens, Neoplasm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41349567
DOI: 10.1146/annurev-med-043024-111400

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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