Article

Collagen-binding integrin α11β1 contributes to joint destruction in arthritic hTNFtg mice

2022-01-14

Abstract excerpt

<h4>Background</h4> In rheumatoid arthritis (RA), fibroblast like synoviocytes (FLS) undergo a “tumor-like” transformation, wherein they develop an aggressive phenotype that is characterized by increased adhesion to components of cartilage extracellular matrix (ECM) and that contributes extensively to joint destruction. The collagen binding integrin α11β1 was previously shown to be involved in similar processes i...

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Literature Corpus work: 8d97b83e-f7b2-54fa-880f-fd49ff977698
DOI: 10.1101/2022.01.14.476301

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