Article

The HECT-type E3 ubiquitin ligase HECTD2 promotes rheumatoid arthritis pathogenesis by mediating p62 degradation and apoptotic resistance in fibroblast-like synoviocytes

2026-06-01

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Rheumatoid arthritis (RA) is characterized by synovial hyperplasia driven by fibroblast-like synoviocytes (FLSs), which exhibit resistance to endoplasmic reticulum (ER) stress-induced apoptosis. However, the molecular mechanisms underlying this pathogenic phenotype remain elusive. <bold>Methods</bold> HECTD2 expression was assessed in the synovial tissue by...

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Literature Corpus work: eb1f9e18-a132-5e93-9774-2028c13184a3
DOI: 10.21203/rs.3.rs-9744873/v1

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