Article
Epigenetic dysregulation underpins tumorigenesis in a cutaneous tumor syndrome
2019-07-01
Abstract excerpt
Patients with CYLD cutaneous syndrome (CCS; syn. Brooke-Spiegler syndrome) carry germline mutations in the tumor suppressor CYLD and develop multiple skin tumors with diverse histophenotypes 1,2 . We comprehensively profiled the genomic landscape of 42 benign and malignant tumors across 13 individuals from four multigenerational families. Novel driver mutations were found in epigenetic modifiers DNMT3A and BCO...
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Identifiers and source
- Literature Corpus work
- c1c4f573-04e2-5b4d-b7fb-504be446ebe9
- DOI
- 10.1101/687459