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Article

ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma

17 May 2019

Abstract excerpt

Spiradenoma and cylindroma are distinctive skin adnexal tumors with sweat gland differentiation and potential for malignant transformation and aggressive behaviour. We present the genomic analysis of 75 samples from 57 representative patients including 15 cylindromas, 17 spiradenomas, 2 cylindroma-spiradenoma hybrid tumors, and 24 low- and high-grade spiradenocarcinoma cases, together with morphologically benign...

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PMID: 31101826
DOI: 10.1038/s41467-019-09979-0

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