Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inherited cylindromas: lessons from a rare tumour.

The Lancet. Oncology - 1 Sept 2015

Rajan Neil, Ashworth Alan

Abstract excerpt

Cylindroma is a rare skin tumour that is inherited in several skin-tumour syndromes caused by germline mutations in the tumour suppressor gene, CYLD. In this Review, we provide insight into the clinical features of patients who develop multiple cylindromas and other related tumours. The CYLD protein is also dysfunctional in various sporadic cancers and we discuss how such dysfunction relates to the role of CYLD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Adenoid Cystic
Share to Deubiquitinating Enzyme CYLD
Share to CYLD gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Counseling

Share to Germ-Line Mutation

Share to Phenotype

Share to Skin Neoplasms

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 26370355
DOI: 10.1016/S1470-2045(15)00245-4

Genes

CYLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inherited cylindromas: lessons from a rare tumour.PMID 26370355Read ↗

Understanding Inherited Cylindromas: Clinical Implications of Gene Discovery.Semantic proximity Read ↗

The cylindromatosis (CYLD) gene and head and neck tumorigenesisSemantic proximity Read ↗

Phenotype diversity in familial cylindromatosis: a frameshift mutation in the tumor suppressor gene CYLD underlies different tumors of skin appendages.Semantic proximity Read ↗

A mutational hotspot in CYLD causing cylindromas: a comparison of phenotypes arising in different genetic backgrounds.Semantic proximity Read ↗

Cylindromatosis and the <i>CYLD</i> gene: new lessons on the molecular principles of epithelial growth controlSemantic proximity Read ↗

Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression.Semantic proximity Read ↗

Overexpression of MYB drives proliferation of CYLD-defective cylindroma cells.Semantic proximity Read ↗

Genetic Testing in CYLD Cutaneous Syndrome: An UpdateSemantic proximity Read ↗

Identification of the familial cylindromatosis tumour-suppressor gene.Semantic proximity Read ↗

A new hereditary cylindromatosis family associated with CYLD1 on chromosome 16.Semantic proximity Read ↗

Phenotype variability in tumor disorders of the skin appendages associated with mutations in the CYLD gene.Semantic proximity Read ↗

CYLD regulates keratinocyte differentiation and skin cancer progression in humansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.