Article
Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo.
Free radical biology & medicine - 1 Jun 2005
Strassburger Maria, Bloch Wilhelm, Sulyok Silke, Schüller Jutta, Keist Alexander F, Schmidt Annette, Wenk Jutta, Peters Thorsten, Wlaschek Meinhard, Lenart Jacek, Krieg Thomas, Hafner Martin, Kümin Angelika, Werner Sabine, Müller Werner, Scharffetter-Kochanek Karin
Abstract excerpt
To circumvent the early lethality of manganese superoxide dismutase (SOD2)-deficient mice, we have used a skin-specific strategy with introduction of loxP sites flanking exon 3 of the SOD2 gene. To our surprise, when breeding a female keratin 14 Cre transgenic mouse to a SOD2 "floxed" male mouse, due to keratin 14 promoter-driven Cre expression in the oocytes, all offspring were heterozygous for SOD2. In sharp...
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