Article

Loss of Myosin-1e biases MMTV-PyMT induced breast cancer towards a differentiated and secretory state

2022-04-27

Abstract excerpt

Expression of the unconventional myosin, Myosin-1e (Myo1e), has been shown to contribute to tumor progression in the MMTV-PyMT mouse model of mammary tumorigenesis and is associated with poor outcome in breast cancer patients. However, the specific effects of Myo1e expression on the mammary tumor cells remain unidentified. Here, we used Myo1e-KO and wild-type (WT) MMTV-PyMT mice on a pure genetic background to fur...

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Literature Corpus work: c1af7e0a-924c-507b-9cb8-6226d17480b1
DOI: 10.1101/2022.04.27.489205

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