Article
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion.
The Journal of biological chemistry - 3 Dec 2004
Williams Terence M, Medina Freddy, Badano Ines, Hazan Rachel B, Hutchinson John, Muller William J, Chopra Neeru G, Scherer Philipp E, Pestell Richard G, Lisanti Michael P
Abstract excerpt
Caveolin-1 (Cav-1) is the principal structural component of caveolae membrane domains in non-muscle cells, including mammary epithelia. There is now clear evidence that caveolin-1 influences the development of human cancers. For example, a dominant-negative mutation (P132L) in the Cav-1 gene has been detected in up to 16% of human breast cancer samples. However, the exact functional role of caveolin-1 remains...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.